Investigation of bone formation using calcium phosphate glass cement in beagle dogs
이승범, Choi Youna, 정의원, Jamiyandorj Otgonbold, 김창성, 이용근, 채증규, 최성호,
소속 상세정보
이승범 ( Lee Seung-Bum ) - Yonsei University College of Dentistry Department of Periodontology Research Institute for Periodontal Regeneration
( Choi Youna ) - Yonsei University College of Dentistry Department of Periodontology Research Institute for Periodontal Regeneration
정의원 ( Jung Ui-Won ) - Yonsei University College of Dentistry Department of Periodontology Research Institute for Periodontal Regeneration
( Jamiyandorj Otgonbold ) - Yonsei University College of Dentistry Department of Periodontology Research Institute for Periodontal Regeneration
김창성 ( Kim Chang-Sung ) - Yonsei University College of Dentistry Department of Periodontology Research Institute for Periodontal Regeneration
이용근 ( Lee Yong-Keun ) - Yonsei University College of Dentistry Department and Research Institute of Dental Biomaterials and Bioengineering
채증규 ( Chai Jung-Kiu ) - Yonsei University College of Dentistry Department of Periodontology Research Institute for Periodontal Regeneration
최성호 ( Choi Seong-Ho ) - Yonsei University College of Dentistry Department of Periodontology Research Institute for Periodontal Regeneration
KMID : 0363020100400030125
Abstract
Purpose Among available biomaterials, bioceramics have drawn special interest due to their bioactivity and the possibility of tailoring their composition. The degradation rate and formulation of bioceramics can be altered to mimic the compositions of the mineral phase of bone. The aim of this study was to investigate the bone formation effect of amorphous calcium phosphate glass cement (CPGC) synthesized by a melting and quenching process.
Methods In five male beagle dogs, 4 × 4 mm 1-wall intrabony defects were created bilaterally at the mesial or distal aspect of the mandibular second and fourth premolars. Each of the four defects was divided according to graft materials: CPGC with collagen membrane (CM), biphasic calcium phosphate (BCP) with CM, CM alone, or a surgical flap operation only. The dogs were sacrificed 8 weeks post-surgery, and block sections of the defects were collected for histologic and histometric analysis.
Results There were significant differences in bone formation and cementum regeneration between the experimental and control groups. In particular, the CPGC and BCP groups showed greater bone formation than the CM and control groups.
Conclusions In conclusion, CPGC was replaced rapidly with an abundant volume of new bone; CPGC also contributed slightly to regeneration of the periodontal apparatus.
키워드
Bone substitutes; Calcium phosphates; Osteogenesis
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